Effects of Liposomes of Different Lipid Composition on In Vitro Growth of Mycobacterium Tuberculosis H37Rv

被引:2
|
作者
Sorokoumova, G. M. [1 ]
Andreevskaya, S. M. [2 ]
Smirnova, T. G. [2 ]
Petrova, E. E. [1 ]
Zhogina, Yu. A. [1 ]
Kalashnikova, T. Yu. [3 ]
Chernousova, L. N. [2 ]
Selishcheva, A. A. [3 ]
Shvets, V. I. [1 ]
机构
[1] MV Lomonosov Moscow Acad Fine Chem Technol, Moscow, Russia
[2] Russian Acad Med Sci, Cent Inst TB, Moscow, Russia
[3] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 117234, Russia
关键词
Mycobacterium tuberculosis H37Rv; in vitro culture; liposomes; phospholipids; cardiolipin; BACILLUS-SUBTILIS; METABOLISM; MECHANISMS; MEMBRANES; DOMAINS;
D O I
10.1007/s10517-010-0819-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The growth of M. tuberculosis H37RV in culture medium was studied after addition of liposomes from different lipids ( phosphatidylcholine, cardiolipin, and glycosphyngolipids). Addition of phosphatidylcholine into culture medium did not modify the growth and multiplication of mycobacteria. Addition of glycosphyngolipids and their mixture with phosphatidylcholine partially inhibited the growth. Addition of cardiolipin inhibited the growth of mycobacteria and even suppressed it, depending on the dose. Presumably, high concentrations of cardiolipin added into the culture medium, can transfer the mycobacteria into an uncultivable state.
引用
收藏
页码:797 / 799
页数:3
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