The Role of microRNA in the Inflammatory Response of Wound Healing

被引：38
|
作者：
Jiang, Yuanyuan [1 ]
Xu, Xiang [1 ]
Xiao, Long [1 ]
Wang, Lihong [1 ]
Qiang, Sheng [1 ]
机构：
[1] Nanjing Univ Chinese Med, Ctr Lab, Zhangjiagang TCM Hosp, Zhangjiagang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
microRNA; skin; wound healing; inflammation; exosomes; NF-KAPPA-B; MESENCHYMAL STEM-CELLS; DENDRITIC CELLS; MACROPHAGES; REPAIR; MIRNA; PROLIFERATION; NEUTROPHILS; MECHANISMS; COMPENDIUM;
D O I：
10.3389/fimmu.2022.852419
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Wound healing, a highly complex pathophysiological response to injury, includes four overlapping phases of hemostasis, inflammation, proliferation, and remodeling. Initiation and resolution of the inflammatory response are the primary requirements for wound healing, and are also key events that determines wound quality and healing time. Currently, the number of patients with persistent chronic wounds has generally increased, which imposes health and economic burden on patients and society. Recent studies have found that microRNA(miRNA) plays an essential role in the inflammation involved in wound healing and may provide a new therapeutic direction for wound treatment. Therefore, this review focused on the role and significance of miRNA in the inflammation phase of wound healing.
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页数：11
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