Biomarkers in traumatic brain injury: a review

被引：26

作者：

Toman, Emma ^{[1
]}

Harrisson, S. ^{[2
]}

Belli, T. ^{[3
,4
]}

机构：

[1] Queen Elizabeth Hosp, Major Trauma Serv, Nuffield House,6th Floor, Birmingham B15 2WB, W Midlands, England

[2] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England

[3] Natl Inst Hlth Res Surg Reconstruct & Microbiol R, Birmingham, W Midlands, England

[4] Univ Birmingham, Birmingham, W Midlands, England

来源：

JOURNAL OF THE ROYAL ARMY MEDICAL CORPS | 2016年 / 162卷 / 02期

关键词：

NEUROSURGERY; NEUROPATHOLOGY; TRAUMA MANAGEMENT; NEURON-SPECIFIC ENOLASE; SPECTRIN BREAKDOWN PRODUCTS; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; HEAD-INJURY; SERUM S-100B; II-SPECTRIN; CLEAVED-TAU; PROTEIN; MARKERS;

D O I：

10.1136/jramc-2015-000517

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Biomarkers allow physiological processes to be monitored, in both health and injury. Multiple attempts have been made to use biomarkers in traumatic brain injury (TBI). Identification of such biomarkers could allow improved understanding of the pathological processes involved in TBI, diagnosis, prognostication and development of novel therapies. This review article aims to cover both established and emerging TBI biomarkers along with their benefits and limitations. It then discusses the potential value of TBI biomarkers to military, civilian and sporting populations and the future hopes for developing a role for biomarkers in head injury management.

引用

页码：103 / 108

页数：6

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