Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles

被引：0
|
作者：
Shailaja, M. [1 ]
Anitha, M. [2 ]
Manjula, A. [1 ]
Rao, B. Vittal [1 ]
机构：
[1] Indian Inst Chem Technol, Organ Div 2, Hyderabad 500007, Andhra Pradesh, India
[2] Matrix Labs, Hyderabad, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 08期
关键词：
1,3,4-Oxadiazoles; chloramine-T; oxidative cyclization; halopyridines; ONE-POT SYNTHESIS; 1,3,4-OXADIAZOLES; MOIETY; ACIDS; MILD;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and previously unreported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4-oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against Staphylococus aureus and Escherichia coli bacteria at 250 mu g/mL concentration.
引用
收藏
页码：1088 / 1097
页数：10
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