Donation after cardiac death kidneys are suitable for pediatric recipients

被引:10
|
作者
MacConmara, Malcolm [1 ,2 ]
El Mokdad, Ali [1 ,2 ]
Gattineni, Jyothsna [3 ]
Hwang, Christine S. [1 ,2 ]
机构
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Surg, Div Surg Transplantat, Dallas, TX USA
[2] Childrens Med Ctr, Div Pediat Transplantat, Dallas, TX 75235 USA
[3] Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Div Nephrol, Dallas, TX USA
关键词
donation after cardiac death; kidney; marginal donors; pediatric; CIRCULATORY DEATH; TRANSPLANTATION; DONORS;
D O I
10.1111/petr.13540
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Despite the high number of children listed for kidney transplantation and shortage of deceased organ donors, there is reluctance to utilize DCD kidneys in pediatric recipients. We examined outcomes in pediatric kidney transplant patients who received a DCD kidney allograft. UNOS database was queried to examine outcomes in all pediatric kidney transplant recipients from 1994 to 2017. Pediatric status was defined as <18 years at the time of transplantation. Recipients were divided by DBD or DCD allograft status. Donor and recipient demographic data were examined. Patient and allograft survival was calculated, and Kaplan-Meier survival curves were generated. A P-value of <0.05 was considered to be significant. A total of 286 pediatric kidney transplant recipients received a DCD allograft. The donors in the DCD group were significantly younger than those in the DBD group (21.7 vs 23.3 years), with a higher KDPI (26.5% vs 22.9%). In the DCD group, the average age at transplant was younger (11.6 vs 12.9 years), with no difference in cold ischemia time or length of stay between the two groups. Rates of delayed graft function were higher in the DCD group, but despite this, there were no significant differences in allograft or patient survival between the groups. There is no difference in allograft survival in pediatric kidney transplant recipients who receive a DCD kidney allograft. DCD kidney allografts are suitable for transplantation in pediatric patients and can greatly expand the donor pool.
引用
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页数:9
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