Improving Objective Measurements of the Tumour-Stroma Ratio in Breast Cancer Using Polarized Light Microscopy

被引:0
|
作者
Sprenger, Jillian [1 ]
Murray, Ciara [2 ]
Lad, Jigar [1 ]
Jones, Blake [1 ]
Thomas, Georgia [1 ]
Nofech-Mozes, Sharon [3 ]
Khorasani, Mohammadali [4 ]
Vitkin, Alex [1 ,5 ]
机构
[1] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
[2] Univ Hlth Network, Lab Med Program, Toronto, ON, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[4] Univ British Columbia, Dept Surg, Victoria, BC, Canada
[5] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada
来源
关键词
INDEPENDENT PREDICTOR; SURVIVAL; CELLS;
D O I
10.1117/12.2615729
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Polarized light microscopy can be used to objectively quantify tumour-stroma ratio (TSR), a prognostic indicator validated in several cancers. Polarimetric results correctly differentiated between high- and low-stroma samples, and future work holds promise for improved separation.
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Toward a quantitative method for estimating tumour-stroma ratio in breast cancer using polarized light microscopy
    Sprenger, Jillian
    Murray, Ciara
    Lad, Jigar
    Jones, Blake
    Thomas, Georgia
    Nofech-Mozes, Sharon
    Khorasani, Mohammadali
    Vitkin, Alex
    BIOMEDICAL OPTICS EXPRESS, 2021, 12 (06): : 3241 - 3252
  • [2] The Prognostic Value of Tumour-stroma Ratio in Triple Negative Breast Cancer
    Moorman, A. M.
    Vink, R.
    Heijmans, H. J.
    van der Palen, J.
    Kouwenhoven, E. A.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S369 - S369
  • [3] Tumour-stroma ratio on the prognosis of colorectal cancer
    Souza da Silva, R.
    Gomes, F. F. N.
    Andrade, J. P.
    Barbosa, L. E. D. M.
    Silva, D. S. G.
    VIRCHOWS ARCHIV, 2022, 481 (SUPPL 1) : S237 - S237
  • [4] Tumour-stroma interactions in breast cancer progression
    Isacke, C.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : S16 - S16
  • [5] The Prognostic Value of Tumour-Stroma Ratio in Triple Negative Breast Cancer.
    Moorman, A. M.
    Vink, R.
    Heijmans, H. J.
    van der Palen, J.
    Kouwenhoven, E. A.
    CANCER RESEARCH, 2011, 71
  • [6] The prognostic value of tumour-stroma ratio in triple-negative breast cancer
    Moorman, A. M.
    Vink, R.
    Heijmans, H. J.
    van der Palen, J.
    Kouwenhoven, E. A.
    EJSO, 2012, 38 (04): : 307 - 313
  • [7] Tumour microenvironment: tumour-stroma ratio and cancer-associated fibroblasts
    Souza da Silva, R. M.
    Pedra Dias, E.
    VIRCHOWS ARCHIV, 2019, 475 : S210 - S210
  • [8] The prognostic value of the tumour-stroma ratio in invasive breast carcinoma
    Mesker, W. E.
    Vangangelt, K.
    Tollenaar, L.
    van Pelt, G.
    Dekker, T.
    Kuppen, P.
    Tollenaar, R.
    VIRCHOWS ARCHIV, 2018, 473 : S52 - S52
  • [9] The prognostic value of the tumour-stroma ratio in invasive breast carcinoma
    Mesker, W. E.
    Vangangelt, K.
    Tollenaar, R.
    EUROPEAN JOURNAL OF CANCER, 2018, 92 : S48 - S48
  • [10] The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer
    Downey, C. L.
    Simpkins, S. A.
    White, J.
    Holliday, D. L.
    Jones, J. L.
    Jordan, L. B.
    Kulka, J.
    Pollock, S.
    Rajan, S. S.
    Thygesen, H. H.
    Hanby, A. M.
    Speirs, V.
    BRITISH JOURNAL OF CANCER, 2014, 110 (07) : 1744 - 1747