Challenges of Conducting Clinical Trials during the SARS-CoV-2 Pandemic: The ASCEND Global Program Experience

被引：0

作者：

Johansen, Kirsten L. ^{[1
]}

Acharya, Anjali ^{[2
]}

Cizman, Borut ^{[3
]}

Cobitz, Alexander R. ^{[3
]}

Correa-Rotter, Ricardo ^{[4
]}

Dasgupta, Indranil ^{[5
,6
]}

Kher, Vijay ^{[7
]}

Lopes, Renato D. ^{[8
]}

Matsumoto, Leonardo ^{[9
]}

Meadowcroft, Amy M. ^{[3
]}

Merege Vieira Neto, Osvaldo ^{[10
]}

Okabe, Marilu ^{[9
]}

Rayner, Brian ^{[11
]}

Silva, Arnold ^{[12
]}

Thomas, Hilary ^{[9
]}

Singh, Ajay K. ^{[13
,14
]}

机构：

[1] Univ Minnesota, Hennepin Healthcare, 730 South 8th St, Minneapolis, MN 55415 USA

[2] Albert Einstein Coll Med, Jacobi Med Ctr, Bronx, NY 10461 USA

[3] GlaxoSmithKline, Collegeville, PA USA

[4] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

[5] Heartlands Hosp, Birmingham, W Midlands, England

[6] Univ Warwick, Coventry, W Midlands, England

[7] Medanta Kidney & Urol Inst, Medanta Med, Gurgaon, India

[8] Duke Hlth, Duke Clin Res Inst, Durham, NC USA

[9] PPD Worldwide Headquarters, Wilmington, NC USA

[10] Serv Nefrol Ribeirao Preto, Sao Paulo, Brazil

[11] Groote Schuur Hosp, Cape Town, South Africa

[12] Boise Kidney & Hypertens Inst, Meridian, ID USA

[13] Brigham & Womens Hosp, Boston, MA 02115 USA

[14] Harvard Med Sch, Boston, MA 02115 USA

来源：

KIDNEY360 | 2022年 / 3卷 / 04期

关键词：

chronic kidney disease; clinical trial; COVID-19; dialysis; pandemics; SARS-CoV-2;

D O I：

10.34067/KID.0006212021

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Key Points The coronavirus disease 2019 pandemic has had an unprecedented effect on health and health care and posed challenges to the conduct of clinical trials. Targeted mitigating strategies, on the basis of early and continued data collection from site surveys, limited disruption to the ASCEND trials. Flexibly allowing hemoglobin assessment at local laboratories to inform randomized treatment dosing was key to limiting the discontinuation of treatment.

引用

页码：728 / 733

页数：6

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