In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease

被引：2

作者：

Besnard, Stephane ^{[1
]}

Decressac, Michael ^{[2
]}

Denise, Pierre ^{[1
]}

机构：

[1] Univ Caen, INSERM, CHRU Caen, F-14032 Caen, France

[2] Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, Poitiers, France

来源：

NEUROREPORT | 2010年 / 21卷 / 07期

关键词：

dopamine; electrophysiology; graft; multiunit recording; Parkinson's disease; substantia nigra; transplanted cells; NIGRAL COMPACTA NEURONS; RAT SUBSTANTIA-NIGRA; ELECTROPHYSIOLOGICAL PROPERTIES; DOPAMINERGIC-NEURONS; NIGROSTRIATAL PATHWAY; SUSPENSION GRAFTS; PARS RETICULATA; TRANSPLANTS; RECONSTRUCTION; IDENTIFICATION;

D O I：

10.1097/WNR.0b013e328337f4ca

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop. NeuroReport 21:485-489 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：485 / 489

页数：5

共 50 条

[41] Deep brain stimulation for Parkinson's disease
Hariz, Marwan
Blomstedtl, Patric
JOURNAL OF INTERNAL MEDICINE, 2022, 292 (05) : 764 - 778
[42] Deep Brain Stimulation in Parkinson's Disease
Mehanna, Raja
Fernandez, Hubert H.
Shukla, Aparna Wagle
Bajwa, Jawad A.
PARKINSONS DISEASE, 2018, 2018
[43] Deep Brain Stimulation for Parkinson's Disease
不详
MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 2009, 51 (1309): : 26 - 27
[44] Deep Brain Stimulation for Parkinson's Disease
Nikolov, Petyo
Groiss, Stefan Jun
Schnitzler, Alfons
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE, 2021, 89 (01/02) : 56 - 63
[45] Deep brain stimulation in Parkinson's disease
Kunstmann, Carolina
Valdivia, Felipe
De Marinis, Alejandro
Ayach, Fredy
Miguel Montes, Jose
Chana-Cuevas, Pedro
REVISTA MEDICA DE CHILE, 2018, 146 (05) : 562 - 569
[46] Deep Brain Stimulation in Parkinson's Disease
Malek, Naveed
NEUROLOGY INDIA, 2019, 67 (04) : 968 - 978
[47] Deep brain stimulation for Parkinson's disease
Lozano, AM
PARKINSONISM & RELATED DISORDERS, 2001, 7 (03) : 199 - 203
[48] Deep brain stimulation in Parkinson's disease
Mehanna R.
Lai E.C.
Translational Neurodegeneration, 2 (1)
[49] Different clinical and in-vivo progression in subtypes of Parkinson's disease
Eggers, C.
Pedrosa, D. J.
Kahraman, D.
Maier, F.
Lewis, C. J.
Fink, G. R.
Schmidt, M.
Timmermann, L.
MOVEMENT DISORDERS, 2012, 27 : S233 - S233
[50] Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease
Mendez, I
Baker, KA
Hong, M
BRAIN RESEARCH REVIEWS, 2000, 32 (01) : 328 - 339

← 1 2 3 4 5 →