In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease

被引：2
|
作者：
Besnard, Stephane [1 ]
Decressac, Michael [2 ]
Denise, Pierre [1 ]
机构：
[1] Univ Caen, INSERM, CHRU Caen, F-14032 Caen, France
[2] Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, Poitiers, France
来源：
NEUROREPORT | 2010年 / 21卷 / 07期
关键词：
dopamine; electrophysiology; graft; multiunit recording; Parkinson's disease; substantia nigra; transplanted cells; NIGRAL COMPACTA NEURONS; RAT SUBSTANTIA-NIGRA; ELECTROPHYSIOLOGICAL PROPERTIES; DOPAMINERGIC-NEURONS; NIGROSTRIATAL PATHWAY; SUSPENSION GRAFTS; PARS RETICULATA; TRANSPLANTS; RECONSTRUCTION; IDENTIFICATION;
D O I：
10.1097/WNR.0b013e328337f4ca
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop. NeuroReport 21:485-489 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：485 / 489
页数：5
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