Incorporation of residual attention modules into two neural networks for low-dose CT denoising

Purpose: The low-dose computed tomography (CT) imaging can reduce the damage caused by x-ray radiation to the human body. However, low-dose CT images have a different degree of artifacts than conventional CT images, and their resolution is lower than that of conventional CT images, which can affect disease diagnosis by clinicians. Therefore, methods for noise-level reduction and resolution improvement in low-dose CT images have inevitably become a research hotspot in the field of low-dose CT imaging. Methods: In this paper, residual attention modules (RAMs) are incorporated into the residual encoder-decoder convolutional neural network (RED-CNN) and generative adversarial network with Wasserstein distance (WGAN) to learn features that are beneficial to improving the performances of denoising networks, and developed models are denoted as RED-CNN-RAM and WGAN-RAM, respectively. In detail, RAM is composed of a multi-scale convolution module and an attention module built on the residual network architecture, where the attention module consists of a channel attention module and a spatial attention module. The residual network architecture solves the problem of network degradation with increased network depth. The function of the attention module is to learn which features are beneficial to reduce the noise level of low-dose CT images to reduce the loss of detail in the final denoising images, which is also the key point of the proposed algorithms. Results: To develop a robust network for low-dose CT image denoising, multidose-level torso phantom images provided by a cooperating equipment vendor are used to train the network, which can improve the network's adaptability to clinical application. In addition, a clinical dataset is used to test the network's migration capabilities and clinical applicability. The experimental results demonstrate that these proposed networks can effectively remove noise and artifacts from multidose CT scans. Subjective and objective analyses of multiple groups of comparison experiments show that the proposed networks achieve good noise suppression performance while preserving the image texture details. Conclusion: In this study, two deep learning network models are developed using multidose-level CT images acquired from a commercial spiral CT scanner. The two network models can reduce and even remove streaking artifacts, and noise from low-dose CT images confirms the effectiveness of the proposed algorithms. (C) 2021 American Association of Physicists in Medicine