Reversible Choriocapillaris Flow Voids in Acute Syphilitic Posterior Placoid Chorioretinitis

Purpose: To report two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) with choriocapillaris flow voids that partially resolved with systemic antibiotic treatment. Methods: Observational case report with multimodal imaging Results: Two young healthy men suffered an acute monocular loss of vision. Spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCT-A) revealed outer retinitis with loss of the ellipsoid layer and choriocapillaris flow voids. Systemic work-up revealed syphilis. Upon systemic treatment with antibiotics, the patients recovered their vision and the OCT and OCT-A abnormalities partially resolved. Conclusions: Transient choriocapillaris flow voids characterize ASPPC and may be responsible for the visual loss seen in these patients.