Characterization of the starvation-survival response of Staphylococcus aureus

被引:165
|
作者
Watson, SP [1 ]
Clements, MO [1 ]
Foster, SJ [1 ]
机构
[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England
关键词
D O I
10.1128/JB.180.7.1750-1758.1998
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The starvation-survival response of Staphylococcus aureus as a result of glucose, amino acid, phosphate, or multiple-nutrient limitation was investigated. Glucose and multiple-nutrient limitation resulted in the loss of viability of about 99 to 99.9% of the population within 2 days. The remaining surviving cells developed increased survival potential, remaining viable for months. Amino acid or phosphate limitation did not lead to the development of a stable starvation-survival state, and cells became nonculturable within 7 days. For multiple-nutrient limitation, the development of the starvation-survival state was cell density dependent, Starvation survival was associated with a decrease in cell size and increase in resistance to acid shock and oxidative stress. There was no evidence for the formation of a viable but nonculturable state during starvation as demonstrated by flow cytometry, Long-term survival of cells was dependent on cell wall and protein biosynthesis. Analysis of [S-35] methionine incorporation and labelled proteins demonstrated that differential protein synthesis occurred deep into starvation.
引用
收藏
页码:1750 / 1758
页数:9
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