Impact of geriatric factors on surgical and prognostic outcomes in elderly patients with soft-tissue sarcoma

R1 surgical margin, higher performance status and high-sensitivity-modified Glasgow prognostic score were significantly associated with poor prognosis in elderly patients with soft-tissue sarcoma. Coexisting factors affected survival period.Patients aged 65 years requiring surgery for soft-tissue sarcoma are a concern in an aging society. We aimed to reveal the association of clinical/geriatric factors with survival period or postoperative events in such patients who underwent surgery. We enrolled patients aged 65 years who underwent surgery for localized soft-tissue sarcoma at five institutions. We retrospectively collected clinical/geriatric factors and laboratory data, and analyzed their association with outcomes using univariate and multivariate analyses. Among the 202 patients included, mean age at presentation was 73 years. Surgical margin was R0 in 139 patients (69%). The Eastern Cooperative Oncology Group performance status was 2 in 15 (7%). Thirty patients (15%) showed thinness (body mass index < 18.49 kg/cm(2)). High-sensitivity-modified Glasgow prognostic score 1 was seen in 52 patients (26%). Multivariate analysis showed that R1 surgical margin was significantly correlated with poor sarcoma-specific survival (hazard ratio for R1 vs. R0, 3.17; P = 0.001) and event-free survival (hazard ratio for R1 vs. R0, 2.56; P < 0.001). Higher Eastern Cooperative Oncology Group performance status was significantly associated with poor sarcoma-specific survival (hazard ratio for 2 vs. 0 or 1, 2.15; P = 0.038), and higher sensitivity-modified Glasgow prognostic score was significantly associated with poor event-free survival (hazard ratio for 1 vs. 0, 1.74; P = 0.046). Severe thinness (body mass index < 16.00) was a risk factor for postoperative events (odds ratio for body mass index < 16.00 vs. 16.00, 8.15, P = 0.010). Negative surgical margin was associated with better survival. Coexisting conditions had an impact on outcomes in elderly soft-tissue sarcoma patients.