Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

被引：98
|
作者：
Saraogi, Ishu [1 ]
Hebda, James A.
Becerril, Jorge [1 ]
Estroff, Lara A. [1 ]
Miranker, Andrew D. [1 ]
Hamilton, Andrew D. [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 04期
基金：
美国国家卫生研究院;
关键词：
alpha-helix mimetics; amyloid beta-peptides; diabetes; helical structures; proteomimetics; SMALL-MOLECULE INHIBITORS; FIBRIL FORMATION; TOXICITY; STATES; MECHANISM; CATALYSIS; FOLDAMER; DESIGN;
D O I：
10.1002/anie.200901694
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：736 / 739
页数：4
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