Mixed-backbone oligonucleotides containing phosphorothioate and methylphosphonate linkages as second generation antisense oligonucleotide

被引：7
|
作者：
Agrawal, S
Jiang, ZW
Zhao, QY
Shaw, D
Sun, D
Saxinger, C
机构：
[1] UNIV ALABAMA,LURLEEN B WALLACE TUMOR INST,BIRMINGHAM,AL 35233
[2] NCI,DIV BASIC SCI,BETHESDA,MD 20892
来源：
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期
关键词：
D O I：
10.1080/07328319708006109
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antisense oligonucleotides are being studied as novel therapeutic agents. To further improve the properties of antisense oligonucleotides, we have synthesized phosphorothioate oligonucleotides containing methylphosphonate linkages at the 5'-end, the 3'-end, or in the center, and have evaluated the impact of these linkages on the biophysical properties, biological properties, and some of the safety parameters.
引用
收藏
页码：927 / 936
页数：10
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