Autophagy: A Potential Link between Obesity and Insulin Resistance

被引：90

作者：

Codogno, Patrice ^{[1
]}

Meijer, Alfred J. ^{[2
]}

机构：

[1] Univ Paris 11, INSERM, UMR984, Fac Pharm, F-92296 Chatenay Malabry, France

[2] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands

来源：

CELL METABOLISM | 2010年 / 11卷 / 06期

关键词：

DISEASE;

D O I：

10.1016/j.cmet.2010.05.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dysregulation of autophagy contributes to aging and to diseases such as neurodegeneration, cardiomyopathy, and cancer. The paper by Yang et al. (2010) in this issue of Cell Metabolism indicates that defective autophagy may also underlie impaired insulin sensitivity in obesity and that upregulating autophagy can combat insulin resistance.

引用

页码：449 / 451

页数：3

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