Perinatal Vitamin A Status in Relation to Neurodevelopmental Outcome at two Years of Age

被引：22
|
作者：
Zhang, Xuan [1 ,2 ]
Chen, Ke [1 ,2 ,4 ]
Wei, Xiao-Ping [2 ,3 ]
Qu, Ping [2 ,3 ]
Liu, You-Xue [2 ,3 ]
Chen, Jie [2 ,3 ]
Li, Ting-Yu [1 ,2 ]
机构：
[1] Chongqing Med Univ, Childrens Hosp, Dept Primary Child Care, Chongqing, Peoples R China
[2] Chongqing Med Univ, Childrens Hosp, Childrens Nutr Res Ctr, Chongqing, Peoples R China
[3] Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Chongqing, Peoples R China
[4] Chengdu Maternal & Children Hlth Care Hosp, Chengdu, Peoples R China
来源：
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH | 2009年 / 79卷 / 04期
基金：
中国国家自然科学基金;
关键词：
vitamin A; children; neurodevelopment; cord blood; Gesell Development Schedule; BIRTH-WEIGHT; NERVOUS-SYSTEM; RETINOIC ACID; COGNITIVE FUNCTION; LIQUID-CHROMATOGRAPHY; ALPHA-TOCOPHEROL; PRETERM INFANTS; STROKE PATIENTS; FETAL; DISEASE;
D O I：
10.1024/0300-9831.79.4.238
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Information about the effect of antioxidant vitamins nutrition during pregnancy on offspring's intellectual development is extremely limited. Objective: To investigate the correlation of antioxidant vitamins (Vitamin A, E and C) at delivery and the neurodevelopment of early childhood. Method: A total of 158 paired maternal-neonatal subjects were recruited. The serum concentrations of vitamin A, E and C in maternal and cord blood after delivery were determined and intellectual development was evaluated by Gesell Development Schedule (GDS) at two years old. Result: After adjusting for potential confounders, vitamin A placental transport ratio (VA-PTR) was positively associated with motor area development quotients (DQ) and average DQ(p<0.01). Cord VA level was positively related with language area and social area DQ (p<0.05). Nevertheless, there was no significant association between cord VE, VC levels, VE PTR or VC PTR and GDS. The adaptive area and average DQ in high cord VA group was higher than those in low VA group (p<0.05). Cord VA level and VA-PTR were positively associated with birth head circumference and birth weight, respectively. Conclusion: Our data suggested that adequate vitamin A at delivery had beneficial influence on neonatal birth outcomes and children's neurodevelopment in later childhood.
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页码：238 / 249
页数：12
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