The propionate of heme binds N4O2 Schiff base antimalarial drug complexes

被引：25

作者：

Ziegler, J ^{[1
]}

Schuerle, T ^{[1
]}

Pasierb, L ^{[1
]}

Kelly, C ^{[1
]}

Elamin, A ^{[1
]}

Cole, KA ^{[1
]}

Wright, DW ^{[1
]}

机构：

[1] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA 15282 USA

来源：

INORGANIC CHEMISTRY | 2000年 / 39卷 / 16期

关键词：

D O I：

10.1021/ic000295h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Schiff base N4O2 complexes offer a flexible template on which to develop novel antimalarial drug complexes that inhibit the aggregation of hemozoin, a detoxification product of the malaria parasite Plasmodium falciparum. The efficacies of these complexes are dependent on the charges of the complexes. Further evidence suggests that these complexes inhibit hemozoin formation via a specific drug/heme propionate salt that prevents the formation of the requisite axial propionato linkage in the repeating dimeric unit of the hemozoin aggregate. [GRAPHICS]

引用

页码：3731 / +

页数：4

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