Synthesis of deuterated 4,4′-diaminodiphenylsulfone (Dapsone) and related analogs

被引：4
|
作者：
Gannett, PM [1 ]
Johnson, EM [1 ]
Grimes, MA [1 ]
Myers, AL [1 ]
Deavers, RE [1 ]
Tracy, TS [1 ]
机构：
[1] W Virginia Univ, Sch Pharm, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2003年 / 46卷 / 02期
关键词：
4,4 '-diaminophenyl sulfone; Dapsone; deuterated; synthesis;
D O I：
10.1002/jlcr.649
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A general scheme for the synthesis of 4,4'-diaminodiphenylsulfone-d(5) (Dapsone) from aniline-d(5) is described. The method may have general application and the preparation of the related analogs, 4,4'-dimethylaminodiphenyl sulfone from aniline-d(5) and 4,4'-dimethoxydiphenyl sulfone from phenol-d(5), is also described. Copyright (C) 2002 John Wiley Sons, Ltd.
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页码：107 / 114
页数：8
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