Phomopsols A and B from the Mangrove Endophytic Fungus Phomopsis sp. xy21: Structures, Neuroprotective Effects, and Biogenetic Relationships

被引：29

作者：

Li, Wan-Shan ^{[1
]}

Hu, Han-Bo ^{[2
]}

Huang, Zhong-Hui ^{[1
]}

Yan, Ren-Jie ^{[1
]}

Tian, Li-Wen ^{[1
]}

Wu, Jun ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, 1838 Guangzhou Ave North, Guangzhou 510515, Guangdong, Peoples R China

[2] Jinan Univ, Coll Pharm, Marine Drugs Res Ctr, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 19期

基金：

中国国家自然科学基金;

关键词：

ALKALOIDS; RHAZINILAM;

D O I：

10.1021/acs.orglett.9b02906

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A polyketide-derived alkaloid featuring a unique 3,4-dihydro-2H-indeno[1,2-b]pyridine 1-oxide motif, named phomopsol A (1), and a highly oxidized polyketide containing a new 3,5-dihydro-2H-2,5-methanobenzo [e][1,4]-dioxepine moiety, named phomopsol B (2), were isolated from the Thai mangrove endophytic fungus Phomopsis sp. xy21, together with the related biosynthetic polyketide 3. The structures of 1-3 were unambiguously established by single-crystal X-ray diffraction analysis (Cu K alpha), and their neuroprotective effects in PC12 cells were evaluated. The biosynthetic origins of 1-3 are proposed.

引用

页码：7919 / 7922

页数：4

共 50 条

[31] Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp A123
Zhang, Wei
Xu, Liyan
Yang, Lishan
Huang, Yaojian
Li, Shengying
Shen, Yuemao
FITOTERAPIA, 2014, 96 : 146 - 151
[32] Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
Chapla, Vanessa Mara
Zeraik, Maria Luiza
Ximenes, Valdecir F.
Zanardi, Lisineia Maria
Lopes, Marcia N.
Cavalheiro, Alberto Jose
Silva, Dulce Helena S.
Young, Maria Claudia M.
da Fonseca, Luiz Marcos
Bolzani, Vanderlan S.
Araujo, Angela Regina
MOLECULES, 2014, 19 (05): : 6597 - 6608
[33] Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Diaporthe sp.
Zang, Le Yun
Wei, Wei
Guo, Ye
Wang, Ting
Jiao, Rui Hua
Ng, Seik Weng
Tan, Ren Xiang
Ge, Hui Ming
JOURNAL OF NATURAL PRODUCTS, 2012, 75 (10): : 1744 - 1749
[34] A NEW GRISEOFULVIN DERIVATIVE FROM THE MANGROVE ENDOPHYTIC FUNGUS Sporothrix SP.
Wen, Lu
Guo, Zhiyong
Li, Qing
Zhang, Dezhi
She, Zhigang
Vrijmoed, L. L. P.
CHEMISTRY OF NATURAL COMPOUNDS, 2010, 46 (03) : 363 - 365
[35] Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.
Lu Wen
Gang Chen
Zhigang She
Chunyan Yan
Juanni Cai
Lei Mu
Russian Chemical Bulletin, 2010, 59 : 1656 - 1659
[36] Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.
Wen, Lu
Chen, Gang
She, Zhigang
Yan, Chunyan
Cai, Juanni
Mu, Lei
RUSSIAN CHEMICAL BULLETIN, 2010, 59 (08) : 1656 - 1659
[37] A new griseofulvin derivative from the mangrove endophytic fungus Sporothrix SP.
Lu Wen
Zhiyong Guo
Qing Li
Dezhi Zhang
Zhigang She
L. L. P. Vrijmoed
Chemistry of Natural Compounds, 2010, 46 : 363 - 365
[38] Bioactive α-pyrone meroterpenoids from mangrove endophytic fungus Penicillium sp.
Ding, Bo
Wang, Zhiyuan
Huang, Xishan
Liu, Yayue
Chen, Wenrui
She, Zhigang
NATURAL PRODUCT RESEARCH, 2016, 30 (24) : 2805 - 2812
[39] Identification and Bioactivity of Compounds from the Mangrove Endophytic Fungus Alternaria sp.
Wang, Jinhua
Ding, Weijia
Wang, Ruimin
Du, Yipeng
Liu, Huanliang
Kong, Xuehua
Li, Chunyuan
MARINE DRUGS, 2015, 13 (07): : 4492 - 4504
[40] Xyloketal H from the mangrove endophytic fungus Xylaria sp. 2508
X. Liu
F. Xu
Y. Zhang
L. Liu
H. Huang
X. Cai
Y. Lin
W. Chan
Russian Chemical Bulletin, 2006, 55 : 1091 - 1092

← 1 2 3 4 5 →