Separation of drugs by packed-column supercritical fluid chromatography

被引：33
|
作者：
Yaku, K
Morishita, F
机构：
[1] Tanabe Seiyaku Co Ltd, Product & Technol Dev Lab, Dept Analyt Chem, Yodogawa Ku, Osaka 5328505, Japan
[2] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Sakyo Ku, Kyoto 6068501, Japan
来源：
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS | 2000年 / 43卷 / 1-3期
关键词：
diltiazem hydrochloride; steroid; enantiomer separation; pharmaceutical analysis; thermodynamics; SFC;
D O I：
10.1016/S0165-022X(00)00086-5
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Packed-column supercritical fluid chromatography (pSFC) has been expected to analyze various kinds of compounds. Many researchers have expected a new chromatographic technique that overcomes the limitations of other techniques, HPLC and GC. In pharmaceutical development, chromatography plays an important role in the evaluation of safety and efficacy of a new compound. This article provides an overview of the separation of drugs by pSFC. The effects of the chromatographic parameters were studied for the separation of steroids. In chiral separation, the successful results were shown and compared with HPLC (C) 2000 Elsevier Science B.V. All rights reserved.
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页码：59 / 76
页数：18
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