Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid:: a comparison with quinupristin-dalfopristin

被引：44

作者：

Raad, II

Hanna, HA

Hachem, RY

Dvorak, T

Arbuckle, RB

Chaiban, G

Rice, LB

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Infect Dis, Infect Control & Employee Hlth Unit 402, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Div Pharma, Houston, TX 77030 USA

[3] Louis Stokes Cleveland VA, Med Serv, Cleveland, OH USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 09期

关键词：

D O I：

10.1128/AAC.48.9.3583-3585.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The susceptibility of 135 vancomycin-resistant Enterococcus faecium bacteremic isolates to linezolid and quinupristin-dalfopristin was determined. All were susceptible to linezolid, while 88% were susceptible to quinupristin-dalfopristin prior to the clinical use of the drugs at our hospital. More than 6 months after their clinical use, a decrease in susceptibility was noted for only linezolid at 83%. This was related in part to a single G2576U gene mutation in domain V of the 23S rRNA gene.

引用

页码：3583 / 3585

页数：3

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