Murine gammaherpesvirus-68 infects microglia and induces high levels of pro-inflammatory cytokine production

Murine gammaherpesvirus-68 (MHV-68) has been established as a tractable model for the study of human herpesvirus infections. Recent associations between herpesvirus infections and inflammatory central nervous system (CNS) disorders, including multiple sclerosis (MS), have prompted us to investigate the susceptibility of cultured microglia and astrocytes to MHV-68 infection. In the present study, we demonstrate that MHV-68 can infect both cell types. Importantly, we show that MHV-68-infected microglia and astrocytes can produce proinflammatory cytokines. Such cytokine production may either contribute to protective host responses to viral challenges or could exacerbate damaging CNS inflammation. (C) 2003 Elsevier Science B.V. All rights. reserved.