Passage of vasoactive intestinal peptide across the blood-brain barrier

被引：56
|
作者：
Dogrukol-Ak, D [1 ]
Banks, WA
Tuncel, N
Tuncel, M
机构：
[1] Anadolu Univ, Fac Pharm, Dept Analyt Chem, TR-26470 Eskisehir, Turkey
[2] Vet Affairs Med Ctr, Sch Med, GRECC, Dept Internal Med,Div Geriatr, St Louis, MO USA
[3] St Louis Univ, St Louis, MO 63103 USA
[4] Osmangazi Univ, Fac Med, Dept Physiol, Eskisehir, Turkey
来源：
PEPTIDES | 2003年 / 24卷 / 03期
关键词：
vasoactive intestinal peptide; blood-brain barrier; high-performance liquid chromatography; unidirectional influx rate; cerebrospinal fluid; intracerebroventricular injection;
D O I：
10.1016/S0196-9781(03)00059-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the ability of vasoactive intestinal peptide (VIP) to cross the blood-brain barrier (BBB), the interface between the peripheral circulation and central nervous system (CNS). VIP labeled with I-131 (I-VIP) and injected intravenously into mice was taken up by brain as determined by multiple-time regression analysis. Excess unlabeled VIP was unable to impede the entry of I-VIP, indicating that passage is by nonsaturable transmembrane diffusion. High pressure liquid chromatography (HPLC) showed the radioactivity entering the brain to be intact I-VIP. After intracerebroventricular (i.c.v.) injection, I-VIP was sequestered by brain, slowing its efflux from the CNS. In summary, VIP crosses the BBB unidirectionally from blood to brain by transmembrane diffusion. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：437 / 444
页数：8
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