Assessing disease activity in psoriasis and psoriatic arthritis: impact on management and therapy

被引:10
|
作者
Chandran, Vinod [1 ,2 ,3 ,4 ]
Maharaj, Ajesh B. [5 ,6 ]
机构
[1] Univ Toronto, Dept Med, Toronto, ON, Canada
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[3] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[4] Krembil Res Inst, Univ Hlth Network, Toronto, ON, Canada
[5] Univ Kwazulu Natal, Prince Mshiyeni Mem Hosp, Nelson R Mandela Sch Med, Dept Internal Med, Durban, South Africa
[6] Univ Amsterdam, Acad Med Ctr, Dept Clin Immunol & Rheumatol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
关键词
Spondyloarthritis; Composite disease activity measures; enthesitis; dactylitis; outcome measures; OF-LIFE INSTRUMENT; PLACEBO-CONTROLLED TRIAL; ANKYLOSING-SPONDYLITIS; CLINICAL-TRIALS; NAIL PSORIASIS; RESPONDER INDEXES; ASSESSMENT TOOLS; SEVERITY INDEX; ULTRASOUND; VALIDATION;
D O I
10.1586/1744666X.2016.1146133
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The management of psoriatic arthritis (PsA) and psoriasis has undergone major advancements over the last decade. This has been made possible, in part, due to the introduction of new therapies for their management, as well as global collaboration in the development of outcome measures and treat- to- target paradigms. In this review article, we discuss how disease activity is measured and the outcome measures that have been recently developed for the management of PsA. The importance of assessing the individual domains as well as global assessments both from the physician and patient perspective, and the development of composite measures are discussed. The newer PsA specific measures are expected to be more commonly used in clinical trials as well as clinical practice.
引用
收藏
页码:573 / 582
页数:10
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