Thermo-sensitive hydrogels for delivering biotherapeutic molecules: A review

被引：161
|
作者：
Huang, Haiqin [1 ]
Qi, Xiaole [1 ]
Chen, Yanhua [2 ]
Wu, Zhenghong [1 ]
机构：
[1] China Pharmaceut Univ, Key Lab Modern Chinese Med, Nanjing 210009, Jiangsu, Peoples R China
[2] Wuxi Childrens Hosp, Dept Pharm, Wuxi 214000, Jiangsu, Peoples R China
来源：
SAUDI PHARMACEUTICAL JOURNAL | 2019年 / 27卷 / 07期
关键词：
Temperature-sensitive; Hydrogels; Biotherapeutic molecules; TEMPERATURE-SENSITIVE HYDROGEL; POLY N-ISOPROPYLACRYLAMIDE; CONTROLLED-RELEASE; DRUG-DELIVERY; CHITOSAN HYDROGEL; BONE REGENERATION; SOLUTE DIFFUSION; IN-VITRO; PH; PEG;
D O I：
10.1016/j.jsps.2019.08.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To date, a variety of delivery systems based on organic or inorganic materials have been investigated. Among them, hydrogels have become one of the most promising field in drug delivery system due to their unique properties. Temperature-sensitive hydrogels, which gelation at physiological temperature, gift the delivery system with excellent spatial and temporal control, and have a widely application in drug delivery, tissue engineering, imaging, and wound dressing. This review provides a brief overview on the concept and classification of temperature-sensitive hydrogels, and covers the application of temperature-sensitive gel systems in delivery of biotherapeutic molecules. (C) 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：990 / 999
页数：10
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