Enzyme-catalyzed C-F bond formation and cleavage

被引：16
|
作者：
Tong, Wei [1 ,2 ]
Huang, Qun [1 ,2 ]
Li, Min [1 ,2 ]
Wang, Jian-bo [1 ,2 ]
机构：
[1] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Phytochem R&D Hunan Prov, Changsha 410081, Hunan, Peoples R China
[2] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Hunan, Peoples R China
来源：
BIORESOURCES AND BIOPROCESSING | 2019年 / 6卷 / 01期
关键词：
Organofluorines; C-F bonds; Enzyme-catalyzed; Degradation; Formation; CARBON-FLUORINE BOND; FLUOROMETABOLITE BIOSYNTHESIS; FLUOROACETATE DEHALOGENASE; PERFLUOROCARBOXYLIC ACIDS; ANTIBIOTIC NUCLEOCIDIN; MICROBIAL-DEGRADATION; CRYSTAL-STRUCTURE; STREPTOMYCES; MECHANISM; PHARMACEUTICALS;
D O I：
10.1186/s40643-019-0280-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Organofluorines are widely used in a variety of applications, ranging from pharmaceuticals to pesticides and advanced materials. The widespread use of organofluorines also leads to its accumulation in the environment, and two major questions arise: how to synthesize and how to degrade this type of compound effectively? In contrast to a considerable number of easy-access chemical methods, milder and more effective enzymatic methods remain to be developed. In this review, we present recent progress on enzyme-catalyzed C-F bond formation and cleavage, focused on describing C-F bond formation enabled by fluorinase and C-F bond cleavage catalyzed by oxidase, reductase, deaminase, and dehalogenase.
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页数：8
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