A Ratiometric and near-Infrared Fluorescent Probe for Imaging Cu2+ in Living Cells and Animals

被引：10

作者：

Guo, Rui ^{[1
]}

Wang, Qiuan ^{[1
]}

Lin, Weiying ^{[1
,2
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Univ Jinan, Sch Mat Sci & Engn, Sch Chem & Chem Engn, Inst Fluorescent Probes Biol Imaging, Jinan 250022, Shandong, Peoples R China

来源：

JOURNAL OF FLUORESCENCE | 2017年 / 27卷 / 05期

关键词：

Fluorescent probe; NIR; Ratiometric; Cu2+; INTERNAL CHARGE-TRANSFER; EMISSION-SPECTRA; SENSOR; CU(II); COPPER; RECOGNITION; IONS; DERIVATIVES; SULFIDE; FRET;

D O I：

10.1007/s10895-017-2102-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have rationally constructed a novel ratiometric and near-infrared Cu2+ fluorescent probe based on a tricarbocyanine chromophore. The new probe NIR-Cu showed a ratiometric fluorescent response to Cu2+ with a large emission wavelength shift (up to 142 nm) in the far-red to near-infrared region. The probe also displayed a large variation in the fluorescence ratio (I-636/I-778) to Cu2+ species with high sensitivity and selectivity. Additionally, the developed probe NIR-Cu was suitable for fluorescence imaging of Cu2+ in living cells and mice.

引用

页码：1655 / 1660

页数：6

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