Total HCV core antigen assay:: A new marker of hepatitis C viremia for monitoring the progress of therapy

被引：43
|
作者：
Zanetti, AR
Romanò, L
Brunetto, M
Colombo, M
Bellati, G
Tackney, C
机构：
[1] Univ Milan, Inst Virol, Sch Med, I-20133 Milan, Italy
[2] Osped Pisa, Unita Operat Gastroenterol & Epatol, Pisa, Italy
[3] Osped Maggiore, Ist Ricovero & Cura, Carattere Sci, I-20122 Milan, Italy
[4] Osped Mariano Comense, Unita Operat Epatol, Como, Italy
[5] Ortho Clin Diagnost, Raritan, NJ USA
来源：
JOURNAL OF MEDICAL VIROLOGY | 2003年 / 70卷 / 01期
关键词：
hepatitis C; total HCV core antigen; HCV RNA;
D O I：
10.1002/jmv.10355
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：27 / 30
页数：4
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