Total HCV core antigen assay:: A new marker of hepatitis C viremia for monitoring the progress of therapy

被引：43

作者：

Zanetti, AR

Romanò, L

Brunetto, M

Colombo, M

Bellati, G

Tackney, C

机构：

[1] Univ Milan, Inst Virol, Sch Med, I-20133 Milan, Italy

[2] Osped Pisa, Unita Operat Gastroenterol & Epatol, Pisa, Italy

[3] Osped Maggiore, Ist Ricovero & Cura, Carattere Sci, I-20122 Milan, Italy

[4] Osped Mariano Comense, Unita Operat Epatol, Como, Italy

[5] Ortho Clin Diagnost, Raritan, NJ USA

来源：

JOURNAL OF MEDICAL VIROLOGY | 2003年 / 70卷 / 01期

关键词：

hepatitis C; total HCV core antigen; HCV RNA;

D O I：

10.1002/jmv.10355

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this assay a valuable new tool in diagnosis and treatment monitoring. Measurement of total core antigen showed a strong dynamic correlation with HCV RNA data and may serve as an alternative direct marker of viral infection. In addition, with the advent of additional treatment protocols, a rapid, reliable assay for changes in HCV load may permit more frequent patient assessment and tailoring of the therapeutic regimen. (C) 2003 Wiley-Liss, Inc.

引用

页码：27 / 30

页数：4

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