Induction of Indistinguishable Gene Expression Patterns in Rats by Vero Cell-Derived and Mouse Brain-Derived Japanese Encephalitis Vaccines

被引：0

作者：

Momose, Haruka ^{[1
]}

Imai, Jun-ichi ^{[2
]}

Hamaguchi, Isao ^{[1
]}

Kawamura, Mika ^{[2
,3
]}

Mizukami, Takuo ^{[1
]}

Naito, Seishiro ^{[1
]}

Masumi, Atsuko ^{[1
]}

Maeyama, Jun-ichi ^{[1
]}

Takizawa, Kazuya ^{[1
]}

Kuramitsu, Madoka ^{[1
]}

Nomura, Nobuo ^{[4
]}

Watanabe, Shinya ^{[2
]}

Yamaguchi, Kazunari ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Safety Res Blood & Biol Prod, Tokyo 2080011, Japan

[2] Tokyo Med & Dent Univ, Dept Clin Informat, Tokyo 1338519, Japan

[3] Medicrome Inc, Tokyo 1510051, Japan

[4] Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Tokyo 1350064, Japan

来源：

JAPANESE JOURNAL OF INFECTIOUS DISEASES | 2010年 / 63卷 / 01期

关键词：

ACUTE DISSEMINATED ENCEPHALOMYELITIS; CONTROL MAQC PROJECT; PERTUSSIS-VACCINE; QUALITY-CONTROL; CEREBROSPINAL-FLUID; CLINICAL-TRIALS; SAFETY CONTROL; VIRUS-VACCINE; MICROARRAY; PERFORMANCE;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Transcriptomics is an objective index that reflects the overall condition of cells or tissues, and transcriptome technology, such as DNA microarray analysis, is now being introduced for the quality control of medical products. In this study, we applied DNA microarray analysis to evaluate the character of Japanese encephalitis (JE) vaccines. When administered into rat peritoneum, Vero cell-derived and mouse brain-derived JE vaccines induced similar gene expression patterns in liver and brain. Body weights and blood biochemical findings were also similar after administration of the two vaccines. Our results suggest that the two JE vaccines are likely to have equivalent characteristics with regard to reactivity in rats.

引用

页码：25 / 30

页数：6

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