Induction of Indistinguishable Gene Expression Patterns in Rats by Vero Cell-Derived and Mouse Brain-Derived Japanese Encephalitis Vaccines

被引：0

作者：

Momose, Haruka ^{[1
]}

Imai, Jun-ichi ^{[2
]}

Hamaguchi, Isao ^{[1
]}

Kawamura, Mika ^{[2
,3
]}

Mizukami, Takuo ^{[1
]}

Naito, Seishiro ^{[1
]}

Masumi, Atsuko ^{[1
]}

Maeyama, Jun-ichi ^{[1
]}

Takizawa, Kazuya ^{[1
]}

Kuramitsu, Madoka ^{[1
]}

Nomura, Nobuo ^{[4
]}

Watanabe, Shinya ^{[2
]}

Yamaguchi, Kazunari ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Safety Res Blood & Biol Prod, Tokyo 2080011, Japan

[2] Tokyo Med & Dent Univ, Dept Clin Informat, Tokyo 1338519, Japan

[3] Medicrome Inc, Tokyo 1510051, Japan

[4] Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Tokyo 1350064, Japan

来源：

JAPANESE JOURNAL OF INFECTIOUS DISEASES | 2010年 / 63卷 / 01期

关键词：

ACUTE DISSEMINATED ENCEPHALOMYELITIS; CONTROL MAQC PROJECT; PERTUSSIS-VACCINE; QUALITY-CONTROL; CEREBROSPINAL-FLUID; CLINICAL-TRIALS; SAFETY CONTROL; VIRUS-VACCINE; MICROARRAY; PERFORMANCE;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Transcriptomics is an objective index that reflects the overall condition of cells or tissues, and transcriptome technology, such as DNA microarray analysis, is now being introduced for the quality control of medical products. In this study, we applied DNA microarray analysis to evaluate the character of Japanese encephalitis (JE) vaccines. When administered into rat peritoneum, Vero cell-derived and mouse brain-derived JE vaccines induced similar gene expression patterns in liver and brain. Body weights and blood biochemical findings were also similar after administration of the two vaccines. Our results suggest that the two JE vaccines are likely to have equivalent characteristics with regard to reactivity in rats.

引用

页码：25 / 30

页数：6

共 50 条

[1] Immunological equivalence between mouse brain-derived and Vero cell-derived Japanese encephalitis vaccines
Abe, Motoharu
Shiosaki, Kouichi
Hammar, Lena
Sonoda, Kengo
Xing, Li
Kuzuhara, Syoji
Kino, Yoichiro
Cheng, R. Holland
VIRUS RESEARCH, 2006, 121 (02) : 152 - 160
[2] Comparison of viral glycosylation using lectin blotting with Vero cell-derived and mouse brain-derived Japanese encephalitis vaccines
Toriniwa, Hiroko
Komiya, Tomoyoshi
VACCINE, 2011, 29 (10) : 1859 - 1862
[3] A Single Dose of Vero Cell-Derived Japanese Encephalitis (JE) Vaccine (Ixiaro) Effectively Boosts Immunity in Travelers Primed With Mouse Brain-Derived JE Vaccines
Erra, Elina O.
Askling, Helena Hervius
Rombo, Lars
Riutta, Jukka
Vene, Sirkka
Yoksan, Sutee
Lindquist, Lars
Pakkanen, Sari H.
Huhtamo, Eili
Vapalahti, Olli
Kantele, Anu
CLINICAL INFECTIOUS DISEASES, 2012, 55 (06) : 825 - 834
[4] Development of Vero cell-derived inactivated Japanese encephalitis vaccine
Sugawara, K
Nishiyama, K
Ishikawa, Y
Abe, M
Sonoda, K
Komatsu, K
Horikawa, Y
Takeda, K
Honda, T
Kuzuhara, S
Kino, Y
Mizokami, H
Mizuno, K
Oka, T
Honda, K
BIOLOGICALS, 2002, 30 (04) : 303 - 314
[5] Phase III Clinical Trials Comparing the Immunogenicity and Safety of the Vero Cell-Derived Japanese Encephalitis Vaccine Encevac with Those of Mouse Brain-Derived Vaccine by Using the Beijing-1 Strain
Miyazaki, Chiaki
Okada, Kenji
Ozaki, Takao
Hirose, Mizuo
Iribe, Kaneshige
Yokote, Hiroyuki
Ishikawa, Yuji
Togashi, Takehiro
Ueda, Kohji
CLINICAL AND VACCINE IMMUNOLOGY, 2014, 21 (02) : 188 - 195
[6] Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine
Woolpert, Tabitha
Staples, J. Erin
Faix, Dennis J.
Nett, Randall J.
Kosoy, Olga I.
Biggerstaff, Brad J.
Johnson, Barbara W.
Sracic, Michael
Fischer, Marc
VACCINE, 2012, 30 (20) : 3090 - 3096
[7] Combating Japanese encephalitis: Vero-cell derived inactivated vaccines and the situation in Japan
Ishikawa, Tomohiro
Konishi, Eiji
FUTURE VIROLOGY, 2010, 5 (06) : 785 - 799
[8] Immunogenicity of single-dose Vero cell-derived Japanese encephalitis vaccine in Japanese adults
Takeshita, Nozomi
Lim, Chang-Kweng
Mizuno, Yasutaka
Shimbo, Takuro
Kotaki, Akira
Ujiie, Mugen
Hayakawa, Kayoko
Kato, Yasuyuki
Kanagawa, Shuzo
Kaku, Mitsuo
Takasaki, Tomohiko
JOURNAL OF INFECTION AND CHEMOTHERAPY, 2014, 20 (3-4) : 238 - 242
[9] Safety profile of the Vero cell-derived Japanese encephalitis virus (JEV) vaccine IXIARO®
Schuller, Elisabeth
Klingler, Anton
Dubischar-Kastner, Katrin
Dewasthaly, Shailesh
Mueller, Zsuzsanna
VACCINE, 2011, 29 (47) : 8669 - 8676
[10] Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children
Chanthavanich, Pornthep
Limkittikul, Kriengsak
Sirivichayakul, Chukiat
Chokejindachai, Watcharee
Hattasingh, Weerawan
Pengsaa, Krisana
Surangsrirat, Surachai
Srisuwannaporn, Termsang
Kaewma, Benjawan
Yoksan, Sutee
Jun, Gao
Zhumu, Bai
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2018, 14 (04) : 900 - 905

← 1 2 3 4 5 →