Mechanism of albuminuria associated with cardiovascular disease and kidney disease

被引：32
|
作者：
Russo, LM
Comper, WD
Osicka, TM
机构：
[1] AusAm Biotechnol Inc, New York, NY 10022 USA
[2] Massachusetts Gen Hosp, Dept Med, Renal Unit, Program Membrane Biol, Charlestown, MA USA
[3] Harvard Univ, Sch Med, Charlestown, MA USA
[4] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3168, Australia
来源：
KIDNEY INTERNATIONAL | 2004年 / 66卷
关键词：
lysosome; albumin degradation; albumm-derived fragments;
D O I：
10.1111/j.1523-1755.2004.09218.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The major underlying factors associated with tissue damage and fibrosis in cardiovascular and kidney disease are the up-regulation and action of growth factors such as transforming growth factor-beta (TGF-Pbeta) and cytokines produced in response to changes in systemic factors, particularly blood pressure or hyperalycemia. This study identifies the relationship of elevated levels of TGF-beta to increased levels of intact albumin in the urine (micro- and macroalbuminuria). This mechanism may be directly linked to the effect of TGF-beta on albumin uptake and the lysosomal breakdown of filtered albumin by proximal tubular cells prior to excretion.
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页码：S67 / S68
页数：2
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