Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities

被引：8
|
作者：
Dhanya, B. P. [1 ,2 ]
Gopalan, Greeshma [1 ,2 ]
Reshmitha, T. R. [3 ]
Saranya, J. [2 ]
Sharathna, P. [1 ,2 ]
Shibi, I. G. [4 ]
Nisha, P. [1 ,3 ]
Radhakrishnan, K. V. [1 ,2 ]
机构：
[1] CSIR NIIST, AcSIR, Thiruvananthapuram 695019, Kerala, India
[2] Natl Inst Interdisciplinary Sci & Technol CSIR, Organ Chem Sect, Thiruvananthapuram 695019, Kerala, India
[3] Natl Inst Interdisciplinary Sci Technol CSIR, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India
[4] Sree Narayana Coll, Dept Chem, Thiruvananthapuram, Kerala, India
来源：
NEW JOURNAL OF CHEMISTRY | 2017年 / 41卷 / 15期
关键词：
GINGER SESQUITERPENE; ZINGIBER-AROMATICUM; SUBTROPICAL GINGER; ALPHA-GLUCOSIDASE; CHEMISTRY; APOPTOSIS; CHEMOPREVENTION; PROLIFERATION; ENZYMES; STRESS;
D O I：
10.1039/c7nj01098b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of zerumbone pendant derivatives were synthesized and evaluated for their alpha-glucosidase, alpha-amylase and glycation inhibition activities. In our study, some of the derivatives showed potent inhibitory activity in micromolar concentration. In addition, investigations were carried out to screen the cytotoxic effects of some selected derivatives against various cancer cell lines viz., A549, HCT116, HeLa, HT1080 and MDAMB231. Two of the derivatives showed potent activity towards HCT116 and HeLa cell lines.
引用
收藏
页码：6960 / 6964
页数：5
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