Increasing Incidence of Early-Onset Colorectal Cancer

被引：208

作者：

Sinicrope, Frank A. ^{[1
,2
]}

机构：

[1] Mayo Clin, Mayo Comprehens Canc Ctr, Dept Oncol, Alix Sch Med, Rochester, MN USA

[2] Mayo Clin, Mayo Comprehens Canc Ctr, Dept Med, Alix Sch Med, Rochester, MN USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2022年 / 386卷 / 16期

关键词：

SUSCEPTIBILITY GENE-MUTATIONS; MISMATCH-REPAIR DEFICIENCY; COLON-CANCER; RECTAL-CANCER; YOUNG-ADULTS; RISK; ASSOCIATION; GERMLINE; PREVALENCE; HEALTH;

D O I：

10.1056/NEJMra2200869

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early-Onset Colorectal CancerEarly-onset disease (at <50 years of age) accounts for 10% of colorectal cancer cases, and the incidence is increasing, particularly in high-income countries. Patients often present with advanced disease in the left colon. One in six patients has deficient DNA mismatch repair. Screening is now recommended to begin at 45 years of age.

引用

页码：1547 / 1558

页数：12

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