Extension of life-span with superoxide dismutase/catalase mimetics

被引：703
|
作者：
Melov, S
Ravenscroft, J
Malik, S
Gill, MS
Walker, DW
Clayton, PE
Wallace, DC
Malfroy, B
Doctrow, SR
Lithgow, GJ [1 ]
机构：
[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
[2] Univ Manchester, Acad Unit Child Hlth, Manchester M13 9PT, Lancs, England
[3] Buck Inst Age Res, Novato, CA 94949 USA
[4] Eukarion, Bedford, MA 01730 USA
[5] Emory Univ, Ctr Mol Med, Atlanta, GA 30322 USA
来源：
SCIENCE | 2000年 / 289卷 / 5484期
关键词：
D O I：
10.1126/science.289.5484.1567
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean Life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of Life-span and that it can be counteracted by pharmacological intervention.
引用
收藏
页码：1567 / 1569
页数：3
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