The roles of GATA-4,-5 and-6 in vertebrate heart development

被引：139
|
作者：
Peterkin, T
Gibson, A
Loose, M
Patient, R [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England
[2] Victor Chang Cardiac Res Inst, Darlinghurst, NSW 2010, Australia
[3] Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2UH, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 01期
基金：
英国医学研究理事会;
关键词：
myocardium; endocardium; development; protein-protein interactions; transcription factors;
D O I：
10.1016/j.semcdb.2004.10.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The transcription factors GATA-4, -5 and -6 are expressed very early in heart tissue. Essential GATA sites have been detected in several cardiac genes and the cardiac GATA factors interact with a wide variety of cofactors which synergistically increase gene expression. These multi-protein transcriptional complexes confer promoter-specificity on the GATA factors and also on the more broadly expressed cofactors. Here we summarise the data on these interactions and represent the conclusions as a GATA factor-based genetic regulatory network for the heart. Of the three cardiac GATAs, GATA-4 is by far the most extensively studied, however, loss-of-function data question its presumed dominance during heart development as opposed to hypertrophy. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：83 / 94
页数：12
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