Genomic approaches to understanding asthma

被引：62
|
作者：
Palmer, LJ
Cookson, WOCM
机构：
[1] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
[3] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44109 USA
[4] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
来源：
GENOME RESEARCH | 2000年 / 10卷 / 09期
关键词：
D O I：
10.1101/gr.143400
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Asthma is the most common chronic childhood disease in developed nations, and it is a complex disease that has high social and economic costs. Asthma and its associated intermediate phenotypes are under a substantial degree of genetic control. The genetic aetiology of asthma offers a means of better understanding its pathogenesis and, thus, improving preventive strategies, diagnostic tools, and therapies. Considerable effort and expense have been expended in attempts to detect genetic loci contributing to asthma susceptibility, and extensive candidate gene studies and a number of whole-genome screens have been undertaken. This article reviews the current state of knowledge of the genetics of asthma, with a focus on genomic approaches to understanding allergic diseases.
引用
收藏
页码：1280 / 1287
页数：8
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