Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

被引：2

作者：

Han, Hyun-Gyu ^{[1
]}

Yoon, Hye-Ryeon ^{[1
]}

Paik, Young-Sook ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Appl Chem, Yongin 446701, South Korea

来源：

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2009年 / 52卷 / 06期

关键词：

anthranilic acid derivatives; anti-amnestic; prolyl endopeptidase inhibitor;

D O I：

10.3839/jksabc.2009.122

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Anthranilic acid derivatives (3-5) containing the long chain components of N-stearoyl, -oleoyl, and -linoleoyl groups were synthesized for the study of prolyl endopeptidase (PEP, EC 3.4.21.26) inhibitory activity. Compounds 3-5 showed competitive PEP inhibition with IC50 values of 2.81, 4.07 and 3.64 mu M respectively, and K-i values of 1.62, 4.10 and 2.77 mu M, respectively.

引用

页码：735 / 738

页数：4

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