Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

被引：2
|
作者：
Han, Hyun-Gyu [1 ]
Yoon, Hye-Ryeon [1 ]
Paik, Young-Sook [1 ]
机构：
[1] Kyung Hee Univ, Dept Appl Chem, Yongin 446701, South Korea
来源：
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2009年 / 52卷 / 06期
关键词：
anthranilic acid derivatives; anti-amnestic; prolyl endopeptidase inhibitor;
D O I：
10.3839/jksabc.2009.122
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Anthranilic acid derivatives (3-5) containing the long chain components of N-stearoyl, -oleoyl, and -linoleoyl groups were synthesized for the study of prolyl endopeptidase (PEP, EC 3.4.21.26) inhibitory activity. Compounds 3-5 showed competitive PEP inhibition with IC50 values of 2.81, 4.07 and 3.64 mu M respectively, and K-i values of 1.62, 4.10 and 2.77 mu M, respectively.
引用
收藏
页码：735 / 738
页数：4
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