The DNA binding activity of the paired box transcription factor Pax-3 is rapidly downregulated during neuronal cell differentiation

被引：12
|
作者：
Reeves, FC
Fredericks, WJ
Rauscher, FJ
Lillycrop, KA
机构：
[1] Univ Southampton, Sch Biol Sci, Dept Biochem, Southampton SO16 7PX, Hants, England
[2] Wistar Inst Anat & Biol, Dept Mol Genet, Philadelphia, PA 19104 USA
来源：
FEBS LETTERS | 1998年 / 422卷 / 01期
关键词：
neuronal cell; cell proliferation; differentiation; Pax-3;
D O I：
10.1016/S0014-5793(97)01598-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mutations in the murine Pax-3 gene lead to a range of developmental abnormalities including deficiencies in sensory and sympathetic neurones. We have investigated Pax-3 expression during neuronal differentiation and show levels of Pax-3 DNA binding decrease upon cell cycle arrest and morphological differentiation. The fall in Pax-3 DNA binding occurs within 1 h of the induction of differentiation and is mediated in part by a decrease in Pax-3 mRNA. This decrease in Pax-3 binding activity precedes any changes in cell proliferation or morphology, suggesting that the downregulation of this transcription factor may be an important prerequisite for the differentiation of neuronal progenitor cells. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码：118 / 122
页数：5
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