Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt

被引：38
|
作者：
Xu, Xiangchao [1 ]
Ai, Yao [1 ]
Wang, Rongzhou [1 ]
Liu, Liping [1 ]
Yang, Jiazhi [1 ]
Li, Feng [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China
来源：
JOURNAL OF CATALYSIS | 2021年 / 395卷
基金：
中国国家自然科学基金;
关键词：
Acceptorless hydrogenative coupling; Ruthenium; Metal-ligand bifunctional catalyst; 2,2 '-bibenzimidazole; Quinolines; IRIDIUM COMPLEX BEARING; ONE-POT SYNTHESIS; TRANSFER HYDROGENATION; 2-AMINOBENZYL ALCOHOL; BIPYRIDONATE LIGAND; BOND ACTIVATION; WATER; OXIDATION; ARYL; CYCLIZATION;
D O I：
10.1016/j.jcat.2020.12.016
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A ruthenium complex bearing a functional 2,2'-bibenzimidazole ligand [(p-cymene)Ru(BiBzImH(2))Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines via acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones in the presence of carbonate salt. It was confirmed that NH units in the ligand are crucial for catalytic activity. The application of this catalytic system for the scale-gram synthesis of biologically active molecular was also undertaken. Notably, this research exhibits new potential of metal-ligand bifuctional catalysts for acceptorless dehydrogenative reactions. (C) 2020 Elsevier Inc. All rights reserved.
引用
收藏
页码：340 / 349
页数：10
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