Anti-promotion effect of chlorophyllin in DMBA-TPA-induced mouse skin carcinogenesis

被引：0

作者：

Kim, J

Yook, JI

Park, KK

Jung, SY

Hong, JC

Kim, KJ

Kim, JA

Chung, WY

机构：

[1] Yonsei Univ, Coll Dent, Oral Canc Res Inst, Dept Oral Pathol,Seodaemun Gu, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Dent, Oral Canc Res Inst, Dept Oral Biol, Seoul 120752, South Korea

来源：

ANTICANCER RESEARCH | 2000年 / 20卷 / 3A期

关键词：

chemoprevention; chlorophyllin; promotion stage; ornithine decarboxylase; proliferating activity; c-jun family;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study aimed to elucidate the inhibitory effects of chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was under-taken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed. CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.

引用

页码：1493 / 1498

页数：6

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