General strategy for the construction of enantiopure pyrrolidine-based alkaloids. Total synthesis of (-)-monomorine

被引：31

作者：

Zhang, Suhong ^{[1
]}

Xu, Liang ^{[1
]}

Miao, Lei ^{[1
]}

Shu, Hong ^{[1
]}

Trudell, Mark L. ^{[1
]}

机构：

[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 08期

关键词：

D O I：

10.1021/jo062532p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantiopure cis-2,5-disubstituted pyrrolidine building block was prepared from cocaine. The synthetic utility of this compound as a chiral building block was demonstrated by a short and efficient synthesis of the pyrrolidine-based alkaloid (-)-monomorine (six steps, 37% overall yield).

引用

页码：3133 / 3136

页数：4

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