Copper deficiency and neurological disorders in man and animals

被引：131

作者：

Zatta, Paolo

Frank, Adrian

机构：

[1] Univ Padua, Dept Biol, CNR, Inst Biomed Technol,Metalloprot Unit, I-35100 Padua, Italy

[2] Swedish Univ Agr Sci, Fac Vet Med & Anim Sci, Dept Clin Chem, SE-75007 Uppsala, Sweden

来源：

BRAIN RESEARCH REVIEWS | 2007年 / 54卷 / 01期

关键词：

copper; copper deficiency; neonatal ataxia; swayback; Bedlington disease; molybdenum; molybdenosis;

D O I：

10.1016/j.brainresrev.2006.10.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Copper metabolism in the brain is far from being completely understood and further studies are needed on the role of copper in the CNS, starting with careful measurements, metal and biological speciation of metabolites on the molecular level, and combining copper concentration in different brain areas with morphological as well as biochemical alteration after Cu-depletion/deficiency. So far a pathological role for copper has been clearly demonstrated in some human genetic diseases (e.g., Menkes' and Wilson's diseases), but other pathological features connected with metal depletion are under investigation in several laboratories. The metabolic interaction between copper and other metal ions in some neurological disorders is also discussed in this contribution. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：19 / 33

页数：15

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