Multicenter Validation of Mean Upper Cervical Cord Area Measurements from Head 3D T1-Weighted MR Imaging in Patients with Multiple Sclerosis

被引:35
|
作者
Liu, Y. [1 ,2 ,5 ,6 ]
Lukas, C. [7 ]
Steenwijk, M. D. [2 ]
Daams, M. [2 ,3 ]
Versteeg, A. [2 ]
Duan, Y. [1 ]
Li, K. [1 ]
Weiler, F. [8 ]
Hahn, H. K. [8 ]
Wattjes, M. P. [2 ]
Barkhof, F. [2 ]
Vrenken, H. [2 ,4 ]
机构
[1] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
[2] Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Neurosci Campus Amsterdam, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Anat & Neurosci, Sect Clin Neurosci, Neurosci Campus Amsterdam, Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Phys & Med Technol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
[5] Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin, Peoples R China
[6] Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Tianjin, Peoples R China
[7] Ruhr Univ Bochum, St Josef Hosp, Dept Diagnost & Intervent Radiol & Nucl Med, Univ Str 150, Bochum, Germany
[8] Fraunhofer MEVIS, Inst Med Image Comp, Bremen, Germany
基金
美国国家科学基金会;
关键词
SPINAL-CORD; ATROPHY; DISABILITY; NORMALIZATION;
D O I
10.3174/ajnr.A4635
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BACKGROUND AND PURPOSE: Spinal cord atrophy is a common and clinically relevant characteristic in multiple sclerosis. We aimed to perform a multicenter validation study of mean upper cervical cord area measurements in patients with multiple sclerosis and healthy controls from head MR images and to explore the effect of gadolinium administration on mean upper cervical cord area measurements. MATERIALS AND METHODS: We recruited 97 subjects from 3 centers, including 60 patients with multiple sclerosis of different disease types and 37 healthy controls. Both cervical cord and head 3D T1-weighted images were acquired. In 11 additional patients from 1 center, head images before and after gadolinium administration and cervical cord images after gadolinium administration were acquired. The mean upper cervical cord area was compared between cervical cord and head images by using intraclass correlation coefficients (ICC) for both consistency (ICCconsist) and absolute (ICCabs) agreement. RESULTS: There was excellent agreement of mean upper cervical cord area measurements from head and cervical cord images in the entire group (ICCabs = 0.987) and across centers and disease subtypes. The mean absolute difference between the mean upper cervical cord area measured from head and cervical cord images was 2 mm(2) (2.3%). Additionally, excellent agreement was found between the mean upper cervical cord area measured from head images with and without gadolinium administration (ICCabs = 0.991) and between the cervical cord and head images with gadolinium administration (ICCabs = 0.992). CONCLUSIONS: Excellent agreement between mean upper cervical cord area measurements on head and cervical cord images was observed in this multicenter study, implying that upper cervical cord atrophy can be reliably measured from head images. Postgadolinium head or cervical cord images may also be suitable for measuring mean upper cervical cord area.
引用
收藏
页码:749 / 754
页数:6
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