Chemoenzymatic Dynamic Kinetic Resolution of Alcohols and Amines

被引：204

作者：

Lee, Jin Hee ^{[1
]}

Han, Kiwon ^{[1
]}

Kim, Mahn-Joo ^{[1
]}

Park, Jaiwook ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, Gyeongbuk, South Korea

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 06期

关键词：

Dynamic kinetic resolution; Transesterification; Enzymes; Alcohols; Amines; RUTHENIUM-CATALYZED RACEMIZATION; ONE-POT SYNTHESIS; ASYMMETRIC TRANSFER HYDROGENATION; ALKALINE-EARTH SUPPORTS; SECONDARY ALCOHOLS; EFFICIENT ROUTE; ENZYMATIC RESOLUTION; CHIRAL AMINES; PALLADIUM CATALYSTS; ENOL ACETATES;

D O I：

10.1002/ejoc.200900935

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dynamic kinetic resolution (DKR) is an attractive process for the transformation of racemic mixtures into optically active compounds. For successful DKR, efficient racemization is required while the kinetic resolution is proceeding, This Micro-review mainly summarizes the recent developments in the DKR of alcohols and amines, based on metal-catalyzed racemization and enzymatic acylation in a single reaction vessel. Related reactions involving precursors of alcohols and amines Such as ketones, enol acetates, and ketoximes are also described. Reaction conditions are arranged according to racemization catalysts, and substrates employed in the DKR are tabulated. Suggested mechanisms for metal-catalyzed racemizations are also summarized.

引用

页码：999 / 1015

页数：17

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