Indicators of oxidative stress in thyroid cancer

被引：0

作者：

Koduru, Bhargav ^{[1
]}

Tejaswini ^{[1
]}

Thakur, Ajit ^{[1
]}

Kamath, Shobha U. ^{[1
]}

Shenoy, Kallya Rajgopal ^{[3
]}

Kamath, Ullas ^{[2
]}

Reshma, K. ^{[4
]}

机构：

[1] Manipal Univ, Kasturba Med Coll, Dept Biochem, Manipal 576104, Karnataka, India

[2] Melaka Manipal Med Coll, Dept Biochem, Manipal 576104, Karnataka, India

[3] Manipal Univ, Kasturba Med Coll, Dept Surg, Manipal 576104, Karnataka, India

[4] Manipal Univ, Kasturba Med Coll, Dept Biochem, Mangalore 575002, India

来源：

INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 2010年 / 47卷 / 02期

关键词：

Thyroid cancer; Carbonyl; Thiols; Myeloperoxidase; FRAP; Free radical; Oxidative damage; ANTIOXIDANT ACTIVITY; FREE-RADICALS; MYELOPEROXIDASE; PROTEINS; ASSAY; DISEASE; PLASMA; DAMAGE; POWER;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p < 0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p < 0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p < 0.001) in their respective levels in thyroid cancer patients, pre- and post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.

引用

页码：121 / 123

页数：3

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