Palladium-catalyzed intramolecular O-arylation of enolates:: Application to benzo[b]furan synthesis

被引：125
|
作者：
Willis, MC [1 ]
Taylor, D
Gillmore, AT
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] Pfizer Global Res & Dev, Chem Res & Dev Dept, Sandwich CT13 9NJ, Kent, England
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 25期
关键词：
D O I：
10.1021/ol047993g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalyst generated from Pd-2(dba)(3) and the ligand DPEphos effects intramolecular C-O bond formation between enolates and aryl halides in the conversion of 1-(2-haloaryl)ketones directly into the corresponding benzofurans. Both cyclic and acyclic ketones are efficient substrates. Thio ketones can also be employed allowing the preparation of the corresponding benzothiophenes.
引用
收藏
页码：4755 / 4757
页数：3
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