Breast Cancer Survival in Relation to the Metastatic Tumor Burden in Axillary Lymph Nodes

被引:84
|
作者
Andersson, Yvette [1 ]
Frisell, Jan
Sylvan, Maria
de Boniface, Jana
Bergkvist, Leif
机构
[1] Uppsala Univ, Cent Hosp, Clin Res Ctr, Dept Surg, SE-72189 Vasteras, Sweden
关键词
PROGNOSTIC-SIGNIFICANCE; STAGE MIGRATION; FOLLOW-UP; MICROMETASTASES; BIOPSY; MANAGEMENT; DISSECTION; CARCINOMA; COHORT; NUMBER;
D O I
10.1200/JCO.2009.24.5001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose The aim of this study was to determine the prognostic significance of lymph node micrometastases in patients with breast cancer. Patients and Methods Between September 2000 and January 2004, 3,369 patients with breast cancer were included in a prospective cohort. According to their lymph node status, they were classified in the following four groups: 2,383 were node negative, 107 had isolated tumor cells, 123 had micrometastases, and 756 had macrometastases. Median follow-up time was 52 months. Kaplan-Meier estimates and the multivariate Cox proportional hazard regression model were used to analyze survival. Results Five-year cause-specific and event-free survival rates were lower for patients with micrometastases (pN1mi) than for node-negative (pN0) patients (94.1% v 96.9% and 79.6% v 87.1%, respectively; P = .020 and P = .032, respectively). There was no significant survival difference between node-negative patients and those with isolated tumor cells. The overall survival of pN1mi and pN0 patients did not differ. Conclusion This study demonstrates a worse prognosis for patients with micrometastases than for node-negative patients.
引用
收藏
页码:2868 / 2873
页数:6
相关论文
共 50 条
  • [41] Are Axillary Lymph Nodes Still Relevant in Breast Cancer ?
    Euhus, David M.
    ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (13) : 4051 - 4053
  • [42] REGRESSION OF AXILLARY LYMPH-NODES IN CANCER OF BREAST
    EDWARDS, MH
    BAUM, M
    MAGAREY, CJ
    BRITISH JOURNAL OF SURGERY, 1972, 59 (10) : 776 - &
  • [43] Micrometastases in Axillary Lymph Nodes and Outcome of Breast Cancer
    Hetterich, Madeleine
    Gerken, Michael
    Ortrnann, Olaf
    Klinkhammer-Schalke, Monika
    Ignatov, Atanas
    ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 : 16 - 17
  • [44] Not all sentinel lymph nodes are equal - A predictive model for axillary burden in early breast cancer
    Sim, Yirong
    Lim, Sue Zann
    Tan, Shaun S.
    Loh, Alvona Z.
    Lim, Cindy
    Madhukumar, Preetha
    Ho, Gay H.
    Tan, Veronique K. M.
    Ong, Kong Wee
    CANCER RESEARCH, 2015, 75
  • [45] The prognostic significance of the percentage of positive/dissected axillary lymph nodes in breast cancer recurrence and survival in patients with one to three positive axillary lymph nodes
    Truong, PT
    Berthelet, E
    Lee, J
    Kader, HA
    Olivotto, IA
    CANCER, 2005, 103 (10) : 2006 - 2014
  • [46] Predictive factors of isolated tumor cells and micrometastases in axillary lymph nodes in breast cancer
    Madsen, Eva V. E.
    Elias, Sjoerd G.
    van Dalen, Thijs
    van Oort, Pouline M. P.
    van Gorp, Joost
    Gobardhan, Paul D.
    Bongers, Vivian
    BREAST, 2013, 22 (05): : 748 - 752
  • [47] Limited Axillary Lymph Node Dissection for More Than Limited Axillary Breast Cancer Tumor Burden
    Meiri, Hila
    Balint-Lahat, Nora
    Maman, Ronny
    Rosin, Danny
    Nachmany, Ido
    Gutman, Mordechai
    Berger, Yaniv
    ANNALS OF SURGICAL ONCOLOGY, 2022, 29 (SUPPL 2) : 415 - 415
  • [48] CALCIFICATIONS IN METASTATIC BREAST-CARCINOMA IN AXILLARY LYMPH-NODES
    HELVIE, MA
    REBNER, M
    SICKLES, EA
    OBERMAN, HA
    AMERICAN JOURNAL OF ROENTGENOLOGY, 1988, 151 (05) : 921 - 922
  • [49] Metastatic breast carcinoma in axillary lymph nodes: In vitro US detection
    Feu, J
    Tresserra, F
    Fabregas, R
    Navarro, B
    Grases, PJ
    Suris, JC
    FernandezCid, A
    Alegret, X
    RADIOLOGY, 1997, 205 (03) : 831 - 835
  • [50] Mapping of Metastatic Level I Axillary Lymph Nodes in Patients with Newly Diagnosed Breast Cancer
    Almahariq, Muayad F.
    Maywood, Michael J.
    Levitin, Ronald B.
    Squires, Bryan S.
    Jawad, Maha S.
    Chen, Peter Y.
    Gustafson, Gregory S.
    Dilworth, Joshua T.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2020, 106 (04): : 811 - 820